Aptus therapy full#
Aptus therapy trial#

O access to post-secondary education or training O employer-recognized soft skills training 200 people who have developmental disabilities, ages 17 to 50+, receive employment supports in Toronto and York region, including: Last year, Aptus impacted over 2400 people in Toronto and York Region of all ages and abilities through the following programs and services:Īptus sees employment as a key strategy to reduce poverty and homelessness for youth and adults who have a developmental disability. Aptus partners with clients to help them transform their promising therapies into valued medicines.Since 1979, Aptus has specialized in supporting people who have developmental disabilities (formerly as MukiBaum Treatment Centres). Projects are delivered by a team of highly experienced drug development experts utilising an extensive network of academic links. In parallel, the company is exploring the potential benefits of using XRad’s dual kinase inhibitors in combination with targeted radionuclides, checkpoint inhibitors, poly adenosine diphosphate-ribose polymerase (PARP) inhibitors and antibody drug conjugates (ADCs).Īptus Clinical Limited is a UK headquartered, clinical Contract Research Organisation that specialises in the design, conduct and delivery of early phase clinical studies with a particular focus in oncology, rare diseases, cell and gene therapies. Initial development efforts are focused on evaluating XRD-0394’s ability to enhance radiation therapy when used in combination. The company’s lead candidate, XRD-0394, is a first-in-class dual inhibitor of ataxia-telangiectasia mutated (ATM) and DNA-dependent protein kinase (DNA-PK). XRad Therapeutics is a privately held, clinical stage biopharmaceutical company focused on developing dual kinase inhibitors for treating cancer. XRD-0394 is not approved for any condition at this time.

Aptus therapy full#

We look forward to working alongside the XRad team to demonstrate the full benefits of this important potential addition to the cancer treatment armamentarium”įor more information about the study, please visit (NCT05002140). Having worked initially with members of our consulting team, recognition of the strength and depth of experience in our operational delivery organisation has been a great endorsement of our capabilities. Jonathan Lewis, co-founder and Chief Commercial Officer at Aptus Clinical commented “We are thrilled that the XRad team entrusted the clinical delivery of their first asset to Aptus.

Successful completion will allow us to rapidly move to the next step in our clinical development” Tona Gilmer, PhD, President, Chief Executive Officer and co-founder of XRad said in a statement: “We are delighted to be working with our clinical CRO partners at Aptus who are managing the delivery of this vital first study in our development programme.

Aptus therapy trial#

Results from this trial will inform the dosing regimen for the company’s planned Phase 1b study. XRD-0394 is a first-in-class, oral, dual kinase inhibitor of both ataxia-telangiectasia mutated and DNA-dependent protein kinase and based on preclinical studies is designed to enhance the effectiveness of radiation therapies. The trial is being conducted at two world renowned centres of excellence: Memorial Sloan Kettering Cancer Center in New York and the Stanford Cancer Institute in Palo Alto, California. This Phase 1a trial will evaluate the safety and tolerability of single ascending doses of XRD-0394 in combination with radiation therapy. As part of Aptus’ full-service delivery capability, the US CRAs, working alongside their UK headquartered clinical operations and data management colleagues, now provide significant geographical extension to Aptus’ current experience delivering early phase oncology, cell & gene therapy and rare disease clinical trials in in the UK and EU.

For XRad, XRD-0394 is their first asset to reach clinical development, whilst for Aptus this is the first study utilising their US-based CRA team. The dosing of the first patient into US based XRad Therapeutics’ Phase 1a study of XRD-0394 in metastatic, locally advanced or recurrent solid tumours, marks a major milestone for XRad and Aptus Clinical.